The Krupina Lab studies mechanisms of genome instability during cancer evolution.
Chromothripsis is a form of genome instability in which one or a few chromosomes undergo extensive fragmentation and rearrangement following errors in cell division and loss of nuclear integrity. By defining the molecular and cellular events that initiate chromosome breakage, we aim to understand how these processes reshape cancer genomes and contribute to tumor aggressiveness and therapy resistance.
Lab News
2025
- First author paper is published in Science: Krupina K, Goginashvili A, Baughn M, Koeppel J, Steele CD, Trivedi P, Jenkins D, Shiau AK, Koga T, Miki S, Furnari FB, Campbell PJ, Alexandrov LB, Cleveland DW. Chromothripsis and ecDNA induced by N4BP2 nuclease-mediated fragmentation of cytoplasm exposed chromosomes // Science, 2025 Dec 11;390(6778):1156-1163. doi: 10.1126/science.ado077
- Iowa Health Care news release: "Scientists uncover enzyme that shatters chromosomes, reshapes cancer genomes."
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